Squamous cell lung carcinoma (conditioned on cigarettes per day)
CLPTM1L · rs459961
0 19162316Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot6Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 8,901 European ancestry cases, 64,477 European ancestry controls, 300 African ancestry cases, 62,112 African ancestry controls; replicated in 4,162 European ancestry cases, 13,599 European ancestry controls, 451 African ancestry cases, 3,779 African ancestry controls.
The effect
Each copy of the A allele carried 0.84 times the odds of Squamous cell lung carcinoma (conditioned on cigarettes per day) (95% confidence interval 0.815-0.861); p = 1 × 10−37.
How common The A allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — in an intron of CLPTM1L.
What each result means
A/ATwo copies of the version the research linked to Squamous cell lung carcinoma (conditioned on cigarettes per day). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Squamous cell lung carcinoma (conditioned on cigarettes per day). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Squamous cell lung carcinoma (conditioned on cigarettes per day). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39366959 · open access
Questions about rs459961
What is rs459961?
rs459961 is a single position in the genome, in or near the CLPTM1L gene. Published research associates it with squamous cell lung carcinoma (conditioned on cigarettes per day). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs459961 linked to?
On MyGeneLog this position is linked to Lung Squamous Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs459961 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs459961 come from?
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 19162316Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot6Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Squamous cell lung carcinoma (conditioned on cigarettes per day) (rs459961). MyGeneLog™. https://www.mygenelog.com/variants/rs459961