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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00847 lower (95% confidence interval 0.0061-0.0109); p = 5 × 10−14.
How common The G allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 11, band 11q13.4 — in an intron of PDE2A.
What each result means
A/ANo copy of the version the research linked to Standing height (UKB data field 50). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Standing height (UKB data field 50). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Standing height (UKB data field 50). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs457556
What is rs457556?
rs457556 is a single position in the genome, in or near the PDE2A gene. Published research associates it with standing height (ukb data field 50). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs457556 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs457556 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs457556 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others7Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Standing height (UKB data field 50) (rs457556). MyGeneLog™. https://www.mygenelog.com/variants/rs457556