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Selective IgA deficiency

ATG13 · rs4565870

Where this position leads

Condition: Selective IgA Deficiency

rs4565870 Condition: Selective IgA Deficiency Selective IgA Deficiency Condition rs4565870 rs4565870 ATG13

What the study found

Who was studied 1,635 European ancestry cases, 4,852 European ancestry controls.

The effect Each copy of the C allele carried 1.38 times the odds of Selective IgA deficiency; p = 7 × 10−10.

How common The C allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 11, band 11p11.2 — between genes, 4.6 kb from DGKZ.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Selective IgA deficiency compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Selective IgA deficiency.
T/T Published research associates this genotype with typical/baseline likelihood of Selective IgA deficiency — no copies of the reported risk allele.
Source

Questions about rs4565870

What is rs4565870?

rs4565870 is a single position in the genome, in or near the ATG13 gene. Published research associates it with selective iga deficiency. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4565870 linked to?

On MyGeneLog this position is linked to Selective IgA Deficiency. The research behind each link, and its sources, are set out on that condition page.

Does having rs4565870 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4565870 come from?

GWAS Catalog, Nat Genet 2016, PMID:27723758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Selective IgA deficiency (rs4565870). MyGeneLog™. https://www.mygenelog.com/variants/rs4565870

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