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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 61,745 African ancestry individuals, 6,967 Asian ancestry individuals, 297,166 European ancestry individuals, 26,644 Hispanic or Latin American individuals.
The effect
Each copy of the A allele shifted the measure 0.0755 lower (95% confidence interval 0.065-0.086); p = 9 × 10−49.
Where it sits Chromosome 10, band 10q26.13 — in an intron of FGFR2.
What ClinVar records
ClassificationBenign for FGFR2-related craniosynostosis; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2026-01-05.
ClinVar record 1168306NM_000141.5(FGFR2):c.109+3899T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Prostate-specific antigen levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Prostate-specific antigen levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Prostate-specific antigen levels. This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39930085 · open access
Questions about rs45631563
What is rs45631563?
rs45631563 is a single position in the genome, in or near the FGFR2 gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs45631563 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs45631563 come from?
GWAS Catalog, Nature genetics 2025, PMID:39930085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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