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Serum total protein levels

TNFRSF13B · rs4561508

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied Up to 25,539 European ancestry individuals, 10,168 Japanese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0401 higher (95% confidence interval 0.031-0.049); p = 2 × 10⁻¹⁸.

How common The T allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 17, band 17p11.2 — in an intron of TNFRSF13B.

What each result means

C/C No copy of the version the research linked to Serum total protein levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Serum total protein levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Serum total protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery and fine mapping of serum protein loci through transethnic meta-analysis

Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V

and 89 more — show all

Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L, Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O' Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP

LifeLines Cohort Study

American journal of human genetics · 2012 · PMID 23022100

Questions about rs4561508

What is rs4561508?

rs4561508 is a single position in the genome, in or near the TNFRSF13B gene. Published research associates it with serum total protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4561508 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4561508 come from?

GWAS Catalog, Am J Hum Genet 2012, PMID:23022100. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Serum total protein levels (rs4561508). MyGeneLog™. https://www.mygenelog.com/variants/rs4561508

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