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Who was studied 17,416 European ancestry cases, 375,455 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.115 higher (95% confidence interval 0.078-0.153); p = 1 × 10−9.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 16, band 16q24.3 — in the 3′ untranslated region of LOC112268179.
What each result means
C/CTwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
Genome medicine · 2021 · PMID 33549134 · open access
Questions about rs45609834
What is rs45609834?
rs45609834 is a single position in the genome, in or near the SPIRE2 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs45609834 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs45609834 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs45609834 come from?
GWAS Catalog, Genome Med 2021, PMID:33549134. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 35211072319Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity1Meta AI10Microsoft · Copilot7Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total35Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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