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High blood pressure / hypertension

MTHFR · rs45603435

Where this position leads

Condition: Blood Pressure

rs45603435 Condition: Blood Pressure Blood Pressure Condition rs45603435 rs45603435 MTHFR

What the study found

Who was studied 191,352 European ancestry cases, 124,316 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0907 higher (95% confidence interval 0.076-0.105); p = 2 × 10−43.

How common The A allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 1, band 1p36.22 — in an intron of MTHFR.

What each result means

A/A Two copies of the version the research linked to High blood pressure / hypertension. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to High blood pressure / hypertension. That is a smaller link than two copies.
G/G No copy of the version the research linked to High blood pressure / hypertension. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs45603435

What is rs45603435?

rs45603435 is a single position in the genome, in or near the MTHFR gene. Published research associates it with high blood pressure / hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs45603435 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs45603435 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs45603435 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High blood pressure / hypertension (rs45603435). MyGeneLog™. https://www.mygenelog.com/variants/rs45603435

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