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Suicide attempts in major depressive disorder

ARL5B · rs45593736

Where this position leads

Condition: Major Depressive Disorder

rs45593736 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs45593736 rs45593736 ARL5B

What the study found

Who was studied 1,622 European ancestry attempters, 8,786 European ancestry nonattempters.

The effect Each copy of the A allele carried 2.38 times the odds of Suicide attempts in major depressive disorder (95% confidence interval 1.75-3.23); p = 3 × 10−8.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 10, band 10p12.31 — in an intron of ARL5B.

What each result means

A/A Two copies of the version the research linked to Suicide attempts in major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Suicide attempts in major depressive disorder. That is a smaller link than two copies.
G/G No copy of the version the research linked to Suicide attempts in major depressive disorder. This is the starting point the study compared everyone against.
Source
GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
Mullins N, Bigdeli TB, Børglum AD, Coleman JRI, Demontis D, Mehta D, Power RA, Ripke S, Stahl EA, Starnawska A, Anjorin A, Corvin A
and 105 more — show all
Sanders AR, Forstner AJ, Reif A, Koller AC, Świątkowska B, Baune BT, Müller-Myhsok B, Penninx BWJH, Pato C, Zai C, Rujescu D, Hougaard DM, Quested D, Levinson DF, Binder EB, Byrne EM, Agerbo E, Streit F, Mayoral F, Bellivier F, Degenhardt F, Breen G, Morken G, Turecki G, Rouleau GA, Grabe HJ, Völzke H, Jones I, Giegling I, Agartz I, Melle I, Lawrence J, Walters JTR, Strohmaier J, Shi J, Hauser J, Biernacka JM, Vincent JB, Kelsoe J, Strauss JS, Lissowska J, Pimm J, Smoller JW, Guzman-Parra J, Berger K, Scott LJ, Jones LA, Azevedo MH, Trzaskowski M, Kogevinas M, Rietschel M, Boks M, Ising M, Grigoroiu-Serbanescu M, Hamshere ML, Leboyer M, Frye M, Nöthen MM, Alda M, Preisig M, Nordentoft M, Boehnke M, O'Donovan MC, Owen MJ, Pato MT, Renteria ME, Budde M, Weissman MM, Wray NR, Bass N, Craddock N, Smeland OB, Andreassen OA, Mors O, Gejman PV, Sklar P, McGrath P, Hoffmann P, McGuffin P, Lee PH, Mortensen PB, Kahn RS, Ophoff RA, Adolfsson R, Van der Auwera S, Djurovic S, Kloiber S, Heilmann-Heimbach S, Jamain S, Hamilton SP, McElroy SL, Lucae S, Cichon S, Schulze TG, Hansen T, Werge T, Air TM, Nimgaonkar V, Appadurai V, Cahn W, Milaneschi Y, Fanous AH, Kendler KS, McQuillin A, Lewis CM
M.R.C.Psych · Dr.Med.Sc · M.R.C.Psych · M.R.C.Psych · Dipl.-Psych · M.R.C.Psych · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium · Bipolar Disorder Working Group of the Psychiatric Genomics Consortium · Schizophrenia Working Group of the Psychiatric Genomics Consortium
The American journal of psychiatry · 2019 · PMID 31164008

Questions about rs45593736

What is rs45593736?

rs45593736 is a single position in the genome, in or near the ARL5B gene. Published research associates it with suicide attempts in major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs45593736 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs45593736 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs45593736 come from?

GWAS Catalog, The American journal of psychiatry 2019, PMID:31164008. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Suicide attempts in major depressive disorder (rs45593736). MyGeneLog™. https://www.mygenelog.com/variants/rs45593736

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