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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 842,717 European ancestry individuals.
The effect
Each copy of the C allele carried 1.04 times the odds of Smoking initiation; p = 4 × 10−18.
Where it sits Chromosome 6, band 6q21 — in an intron of MFSD4B.
What each result means
C/CTwo copies of the version the research linked to Smoking initiation. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Smoking initiation. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Smoking initiation. This is the starting point the study compared everyone against.
Nature communications · 2020 · PMID 33082346 · open access
Questions about rs455650
What is rs455650?
rs455650 is a single position in the genome, in or near the REV3L gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs455650 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs455650 come from?
GWAS Catalog, Nature communications 2020, PMID:33082346. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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