Standard
Hypospadias
DGKK · rs4554617
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Hypospadias — no copies of the reported risk allele.
A/C
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hypospadias.
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hypospadias compared to the general population.
Source
Genome-wide association analyses identify variants in developmental genes associated with hypospadias
Geller F,
Feenstra B,
Carstensen L,
Pers TH,
van Rooij IA,
Körberg IB,
Choudhry S,
Karjalainen JM,
Schnack TH,
Hollegaard MV,
Feitz WF,
Roeleveld N
and 7 more — show all
Nature genetics · 2014 · PMID 25108383
Questions about rs4554617
What is rs4554617?
rs4554617 is a single position in the genome, in or near the DGKK gene. Published research associates it with hypospadias. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4554617 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4554617 come from?
GWAS Catalog, Nat Genet 2014, PMID:25108383. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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