PCSK9 · rs45448095
Where this position leads
Condition: Coronary Artery Disease
What the study found
Who was studied 2,022 European ancestry individuals without statin treatment, 1,268 European ancestry individuals with statin treatment.
The effect Each copy of the T allele shifted the measure 0.084 lower (95% confidence interval 0.06-0.108); p = 4 × 10−12.
How common The T allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 1, band 1p32.3 — in the 5′ untranslated region of PCSK9.
What ClinVar records
Classification
Benign for Hypercholesterolemia, familial, 1, Hypobetalipoproteinemia, Hypercholesterolemia, autosomal dominant, 3, Familial hypercholesterolemia; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2022-07-01.
ClinVar record 36666 NM_174936.4(PCSK9):c.-64C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs45448095 is a single position in the genome, in or near the PCSK9 gene. Published research associates it with plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Circulation. Genomic and precision medicine 2018, PMID:29748315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (rs45448095). MyGeneLog™. https://www.mygenelog.com/variants/rs45448095