Standard

Platelet large cell ratio

YIF1B · rs45437199

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 37,935 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0587 SD units lower (95% confidence interval 0.041-0.077); p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — a missense change in YIF1B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Platelet large cell ratio compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Platelet large cell ratio.

G/G Published research associates this genotype with typical/baseline likelihood of Platelet large cell ratio — no copies of the reported risk allele.

Source

A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology

Akbari P, Vuckovic D, Stefanucci L, Jiang T, Kundu K, Kreuzhuber R, Bao EL, Collins JH, Downes K, Grassi L, Guerrero JA, Kaptoge S

and 20 more — show all

Nature communications · 2023 · PMID 37596262 · open access

Questions about rs45437199

What is rs45437199?

rs45437199 is a single position in the genome, in or near the YIF1B gene. Published research associates it with platelet large cell ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs45437199 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs45437199 come from?

GWAS Catalog, Nature communications 2023, PMID:37596262. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet large cell ratio (rs45437199). MyGeneLog™. https://www.mygenelog.com/variants/rs45437199

← See all variants