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Who was studied 424,305 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0576 higher (95% confidence interval 0.052-0.063); p = 4 × 10−90.
How common The A allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 1, band 1q41 — in an intron of PTPN14.
What each result means
A/ATwo copies of the version the research linked to height (mean, inv-normal transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to height (mean, inv-normal transformed). That is a smaller link than two copies.
G/GNo copy of the version the research linked to height (mean, inv-normal transformed). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs4535974
What is rs4535974?
rs4535974 is a single position in the genome, in or near the PTPN14 gene. Published research associates it with height (mean, inv-normal transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4535974 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does having rs4535974 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4535974 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 10226Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others6Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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