1 20123113Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 29,435 European ancestry cases, 799 African American cases, 157,769 European ancestry controls, 14,353 African American controls.
The effect
Each copy of the T allele carried 1.14 times the odds of Venous thromboembolism (95% confidence interval 1.11-1.16); p = 3 × 10−29.
Where it sits Chromosome 1, band 1q24.2 — a missense change in F5.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Thrombophilia due to activated protein C resistance, Congenital factor V deficiency; criteria provided, conflicting classifications (1 of 4 stars, 9 submitters), last evaluated 2026-02-04.
ClinVar record 255200NM_000130.5(F5):c.2573A>G (p.Lys858Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Venous thromboembolism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Venous thromboembolism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Venous thromboembolism. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4524 is a single position in the genome, in or near the F5 gene. Published research associates it with venous thromboembolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4524 linked to?
On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
Does rs4524 affect how medicines work?
F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4524 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4524 come from?
GWAS Catalog, Blood 2019, PMID:31420334. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 20123113Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others13Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.