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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 37,850 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry cases, 556,334 European, East Asian, African, South Asian, Middle Eastern, Admixed or unknown ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0708 log odds ratio higher (95% confidence interval 0.048-0.093); p = 5 × 10−10.
What each result means
A/ATwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs4514263
What is rs4514263?
rs4514263 is a single position in the genome, in or near the VAV3 gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4514263 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4514263 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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