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Who was studied 342,566 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0368 higher (95% confidence interval 0.031-0.043); p = 3 × 10−35.
Where it sits Chromosome 1, band 1q25.2 — between genes, 93.2 kb from SEC16B.
What each result means
C/CTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Scientific reports · 2024 · PMID 38538606 · open access
Questions about rs4509539
What is rs4509539?
rs4509539 is a single position in the genome, in or near the near SEC16B gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4509539 linked to?
On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Does having rs4509539 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4509539 come from?
GWAS Catalog, Scientific reports 2024, PMID:38538606. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 121227Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others7Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs4509539). MyGeneLog™. https://www.mygenelog.com/variants/rs4509539