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Body mass index

TBC1D10B · rs4500754

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,122,049 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0223 lower (95% confidence interval 0.018-0.027); p = 4 × 10−20.

Where it sits Chromosome 16, band 16p11.2 — in an intron of TBC1D10B.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Body mass index — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body mass index.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body mass index compared to the general population.
Source
Genomics and phenomics of body mass index reveals a complex disease network
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT
and 26 more — show all
Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, Sun YV, O'Donnell CJ
VA Million Veteran Program
Nature communications · 2022 · PMID 36581621 · open access

Questions about rs4500754

What is rs4500754?

rs4500754 is a single position in the genome, in or near the TBC1D10B gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4500754 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4500754 come from?

GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs4500754). MyGeneLog™. https://www.mygenelog.com/variants/rs4500754

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