Sensitive

Breast cancer

near LINC02181 · rs4496150

Where this position leads

What the study found

Who was studied 24,206 East Asian ancestry cases, 24,775 East Asian ancestry controls, 122,977 European ancestry cases, 105,974 European ancestry controls; replicated in 10,829 East Asian ancestry cases, 10,996 East Asian ancestry controls, 5,958 Asian ancestry cases, 5,684 Asian ancestry controls.

The effect Each copy of the A allele carried 0.96 times the odds of Breast cancer (95% confidence interval 0.95-0.97); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 16, band 16q24.2 — between genes, 6.2 kb from LINC02181.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Breast cancer compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Breast cancer.

C/C Published research associates this genotype with typical/baseline likelihood of Breast cancer — no copies of the reported risk allele.

Source

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Bolla MK, Dennis J, Wang Q, Yang Y, Shi J

and 50 more — show all

Guo X, Li B, Tao R, Aronson KJ, Chan KYK, Chan TL, Gao YT, Hartman M, Kee Ho W, Ito H, Iwasaki M, Iwata H, John EM, Kasuga Y, Soon Khoo U, Kim MK, Kong SY, Kurian AW, Kwong A, Lee ES, Li J, Lophatananon A, Low SK, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH, Shen CY, Shin MH, Spinelli JJ, Takahashi A, Tseng C, Tsugane S, Wu AH, Xiang YB, Yamaji T, Zheng Y, Milne RL, Dunning AM, Pharoah PDP, García-Closas M, Teo SH, Shu XO, Kang D, Easton DF, Simard J, Zheng W

Nature communications · 2020 · PMID 32139696 · open access

Questions about rs4496150

What is rs4496150?

rs4496150 is a single position in the genome, in or near the near LINC02181 gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4496150 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4496150 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4496150 come from?

GWAS Catalog, Nature communications 2020, PMID:32139696. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Breast cancer (rs4496150). MyGeneLog™. https://www.mygenelog.com/variants/rs4496150

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