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Asthma

GLB1 · rs4491851

Where this position leads

Condition: Asthma

What the study found

Who was studied 40,544 European ancestry cases, 300,671 European ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Asthma (95% confidence interval 1.05-1.08); p = 3 × 10⁻¹⁹.

Where it sits Chromosome 3, band 3p22.3 — in an intron of GLB1.

What each result means

A/A Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Asthma. That is a smaller link than two copies.

G/G No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.

Source

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Ferreira MAR, Mathur R, Vonk JM, Szwajda A, Brumpton B, Granell R, Brew BK, Ullemar V, Lu Y, Jiang Y, Magnusson PKE, Karlsson R

and 4 more — show all

Hinds DA, Paternoster L, Koppelman GH, Almqvist C

23andMe Research Team · eQTLGen Consortium · BIOS Consortium

American journal of human genetics · 2019 · PMID 30929738

Questions about rs4491851

What is rs4491851?

rs4491851 is a single position in the genome, in or near the GLB1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4491851 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs4491851 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4491851 come from?

GWAS Catalog, American journal of human genetics 2019, PMID:30929738. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs4491851). MyGeneLog™. https://www.mygenelog.com/variants/rs4491851

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