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Acne (severe)

FGF2 · rs4487353

Where this position leads

What the study found

Who was studied 5,602 European ancestry cases, 21,120 European ancestry controls.

The effect Each copy of the G allele carried 1.14 times the odds of Acne (severe) (95% confidence interval 1.09-1.20); p = 2 × 10⁻⁹.

How common The G allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 4, band 4q28.1 — between genes, 13.2 kb from AFG2A.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Acne (severe) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acne (severe).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acne (severe) compared to the general population.

Source

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Petridis C, Navarini AA, Dand N, Saklatvala J, Baudry D, Duckworth M, Allen MH, Curtis CJ, Lee SH, Burden AD, Layton A, Bataille V

and 9 more — show all

Pink AE, Carlavan I, Voegel JJ, Spector TD, Trembath RC, McGrath JA, Smith CH, Barker JN, Simpson MA

Acne Genetic Study Group

Nature communications · 2018 · PMID 30542056 · open access

Questions about rs4487353

What is rs4487353?

rs4487353 is a single position in the genome, in or near the FGF2 gene. Published research associates it with acne (severe). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4487353 linked to?

On MyGeneLog this position is linked to Severe Acne. The research behind each link, and its sources, are set out on that condition page.

Does having rs4487353 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4487353 come from?

GWAS Catalog, Nat Commun 2018, PMID:30542056. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Acne (severe) (rs4487353). MyGeneLog™. https://www.mygenelog.com/variants/rs4487353

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