Standard

Diacylglycerol (18:0/22:6) (Model 2)

near RP1L1 · rs4484649

What the study found

Who was studied 6,915 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.117 lower; p = 5 × 10−11.

Where it sits Chromosome 8, band 8p23.1 — between genes, 1.8 kb from RP1L1.

What each result means

A/A Two copies of the version the research linked to Diacylglycerol (18:0/22:6) (Model 2). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Diacylglycerol (18:0/22:6) (Model 2). That is a smaller link than two copies.
C/C No copy of the version the research linked to Diacylglycerol (18:0/22:6) (Model 2). This is the starting point the study compared everyone against.
Source

Questions about rs4484649

What is rs4484649?

rs4484649 is a single position in the genome, in or near the near RP1L1 gene. Published research associates it with diacylglycerol (18:0/22:6) (model 2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4484649 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4484649 come from?

GWAS Catalog, Nature communications 2026, PMID:42069741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Diacylglycerol (18:0/22:6) (Model 2) (rs4484649). MyGeneLog™. https://www.mygenelog.com/variants/rs4484649

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