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Major depressive disorder

CRTAP · rs4478037

Where this position leads

Condition: Major Depressive Disorder

rs4478037 Condition: Major Depressive Disorder Major Depressive Disorder Condition rs4478037 rs4478037 CRTAP

What the study found

Who was studied 6,997 European ancestry female cases, 16,172 European ancestry female controls, 3,852 European ancestry male cases, 16,034 European ancestry male controls.

The effect Each copy of the A allele shifted the measure 0.29 higher (95% confidence interval 0.19-0.39); p = 2 × 10−8.

How common The A allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 3, band 3p22.3 — in an intron of CRTAP.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Major depressive disorder compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Major depressive disorder.
G/G Published research associates this genotype with typical/baseline likelihood of Major depressive disorder — no copies of the reported risk allele.
Source
Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
Hall LS, Adams MJ, Arnau-Soler A, Clarke TK, Howard DM, Zeng Y, Davies G, Hagenaars SP, Maria Fernandez-Pujals A, Gibson J, Wigmore EM, Boutin TS
and 7 more — show all
Hayward C, Scotland G, Porteous DJ, Deary IJ, Thomson PA, Haley CS, McIntosh AM
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Translational psychiatry · 2018 · PMID 29317602 · open access

Questions about rs4478037

What is rs4478037?

rs4478037 is a single position in the genome, in or near the CRTAP gene. Published research associates it with major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4478037 linked to?

On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs4478037 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4478037 come from?

GWAS Catalog, Transl Psychiatry 2018, PMID:29317602. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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