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Who was studied 12,074 European, African, Admixed American, Asian or unknown ancestry cases, 15,833 European, African, Admixed American, Asian or unknown ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 5 × 10−22.
Where it sits Chromosome 19, band 19q13.32 — in a regulatory region of APOE.
What each result means
G/GNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025 · PMID 39998322 · open access
Questions about rs446037
What is rs446037?
rs446037 is a single position in the genome, in or near the APOE gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs446037 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does rs446037 affect how medicines work?
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs446037 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs446037 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 142129Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others9Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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