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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.333 higher (95% confidence interval 0.23-0.43); p = 6 × 10−11.
Where it sits Chromosome 3, band 3p21.1 — in an intron of CACNA1D.
What each result means
C/CTwo copies of the version the research linked to interleukin-17 receptor B levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to interleukin-17 receptor B levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to interleukin-17 receptor B levels. This is the starting point the study compared everyone against.
Nature communications · 2017 · PMID 28240269 · open access
Questions about rs4453827
What is rs4453827?
rs4453827 is a single position in the genome, in or near the CACNA1D gene. Published research associates it with interleukin-17 receptor b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4453827 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4453827 come from?
GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
interleukin-17 receptor B levels (rs4453827). MyGeneLog™. https://www.mygenelog.com/variants/rs4453827