Standard
Social communication problems
XIRP1 · rs4453791
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Social communication problems compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Social communication problems.
T/T
Published research associates this genotype with typical/baseline likelihood of Social communication problems — no copies of the reported risk allele.
Source
Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence
St Pourcain B,
Skuse DH,
Mandy WP,
Wang K,
Hakonarson H,
Timpson NJ,
Evans DM,
Kemp JP,
Ring SM,
McArdle WL,
Golding J,
Smith GD
Molecular autism · 2014 · PMID 24564958 · open access
Questions about rs4453791
What is rs4453791?
rs4453791 is a single position in the genome, in or near the XIRP1 gene. Published research associates it with social communication problems. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4453791 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4453791 come from?
GWAS Catalog, Mol Autism 2014, PMID:24564958. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants