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Body mass index

NFU1 · rs4453725

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

rs4453725 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs4453725 rs4453725 NFU1

What the study found

Who was studied 1,122,049 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0106 lower (95% confidence interval 0.0081-0.0131); p = 3 × 10−15.

Where it sits Chromosome 2, band 2p13.3 — a missense change in NFU1.

What ClinVar records

Classification Benign for Multiple mitochondrial dysfunctions syndrome 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 10 submitters), last evaluated 2026-02-03. ClinVar record 138516 NM_001002755.4(NFU1):c.74T>A (p.Met25Lys)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genomics and phenomics of body mass index reveals a complex disease network
Huang J, Huffman JE, Huang Y, Do Valle Í, Assimes TL, Raghavan S, Voight BF, Liu C, Barabási AL, Huang RDL, Hui Q, Nguyen XT
and 26 more — show all
Ho YL, Djousse L, Lynch JA, Vujkovic M, Tcheandjieu C, Tang H, Damrauer SM, Reaven PD, Miller D, Phillips LS, Ng MCY, Graff M, Haiman CA, Loos RJF, North KE, Yengo L, Smith GD, Saleheen D, Gaziano JM, Rader DJ, Tsao PS, Cho K, Chang KM, Wilson PWF, Sun YV, O'Donnell CJ
VA Million Veteran Program
Nature communications · 2022 · PMID 36581621 · open access

Questions about rs4453725

What is rs4453725?

rs4453725 is a single position in the genome, in or near the NFU1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4453725 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs4453725 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4453725 come from?

GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs4453725). MyGeneLog™. https://www.mygenelog.com/variants/rs4453725

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