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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 481,874 European ancestry individuals, 11,819 Hispanic cases, 20,869 Hispanic controls, 18,216 African ancestry cases, 64,127 African ancestry controls.
The effect
Each copy of the T allele shifted the measure 6.45 z score higher; p = 1 × 10−10.
How common The T allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — between genes, 45.6 kb from ISG20.
What each result means
G/GNo copy of the version the research linked to Tinnitus. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Tinnitus. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Tinnitus. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 38242899 · open access
Questions about rs4453453
What is rs4453453?
rs4453453 is a single position in the genome, in or near the near ISG20 gene. Published research associates it with tinnitus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4453453 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4453453 come from?
GWAS Catalog, Nature communications 2024, PMID:38242899. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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