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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,941 European, Hispanic or African American individuals; replicated in up to 2,466 African American individuals, up to 15,619 European ancestry individuals, 1,734 Hispanic ancestry children.
The effect
Each copy of the C allele shifted the measure 0.156 higher (95% confidence interval 0.13-0.19); p = 4 × 10−23.
How common The C allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 4, band 4q13.2 — between genes, 19.9 kb from UGT2B15.
What each result means
A/ANo copy of the version the research linked to Metabolite levels (androsterone sulfate). This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Metabolite levels (androsterone sulfate). That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Metabolite levels (androsterone sulfate). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 37253714 · open access
Questions about rs4443356
What is rs4443356?
rs4443356 is a single position in the genome, in or near the near UGT2B15 gene. Published research associates it with metabolite levels (androsterone sulfate). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4443356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4443356 come from?
GWAS Catalog, Nature communications 2023, PMID:37253714. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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