Standard
Estimated glomerular filtration rate
FAM49A · rs4441471
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 567,460 European ancestry individuals; replicated in 216,518 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0022 higher (95% confidence interval 0.0014-0.003); p = 3 × 10−10.
How common The A allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 2, band 2p24.2 — between genes, 15.3 kb from CYRIA.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Estimated glomerular filtration rate compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Estimated glomerular filtration rate.
G/G
Published research associates this genotype with typical/baseline likelihood of Estimated glomerular filtration rate — no copies of the reported risk allele.
Source
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Wuttke M,
Li Y,
Li M,
Sieber KB,
Feitosa MF,
Gorski M,
Tin A,
Wang L,
Chu AY,
Hoppmann A,
Kirsten H,
Giri A
and 315 more — show all
Chai JF,
Sveinbjornsson G,
Tayo BO,
Nutile T,
Fuchsberger C,
Marten J,
Cocca M,
Ghasemi S,
Xu Y,
Horn K,
Noce D,
van der Most PJ,
Sedaghat S,
Yu Z,
Akiyama M,
Afaq S,
Ahluwalia TS,
Almgren P,
Amin N,
Ärnlöv J,
Bakker SJL,
Bansal N,
Baptista D,
Bergmann S,
Biggs ML,
Biino G,
Boehnke M,
Boerwinkle E,
Boissel M,
Bottinger EP,
Boutin TS,
Brenner H,
Brumat M,
Burkhardt R,
Butterworth AS,
Campana E,
Campbell A,
Campbell H,
Canouil M,
Carroll RJ,
Catamo E,
Chambers JC,
Chee ML,
Chee ML,
Chen X,
Cheng CY,
Cheng Y,
Christensen K,
Cifkova R,
Ciullo M,
Concas MP,
Cook JP,
Coresh J,
Corre T,
Sala CF,
Cusi D,
Danesh J,
Daw EW,
de Borst MH,
De Grandi A,
de Mutsert R,
de Vries APJ,
Degenhardt F,
Delgado G,
Demirkan A,
Di Angelantonio E,
Dittrich K,
Divers J,
Dorajoo R,
Eckardt KU,
Ehret G,
Elliott P,
Endlich K,
Evans MK,
Felix JF,
Foo VHX,
Franco OH,
Franke A,
Freedman BI,
Freitag-Wolf S,
Friedlander Y,
Froguel P,
Gansevoort RT,
Gao H,
Gasparini P,
Gaziano JM,
Giedraitis V,
Gieger C,
Girotto G,
Giulianini F,
Gögele M,
Gordon SD,
Gudbjartsson DF,
Gudnason V,
Haller T,
Hamet P,
Harris TB,
Hartman CA,
Hayward C,
Hellwege JN,
Heng CK,
Hicks AA,
Hofer E,
Huang W,
Hutri-Kähönen N,
Hwang SJ,
Ikram MA,
Indridason OS,
Ingelsson E,
Ising M,
Jaddoe VWV,
Jakobsdottir J,
Jonas JB,
Joshi PK,
Josyula NS,
Jung B,
Kähönen M,
Kamatani Y,
Kammerer CM,
Kanai M,
Kastarinen M,
Kerr SM,
Khor CC,
Kiess W,
Kleber ME,
Koenig W,
Kooner JS,
Körner A,
Kovacs P,
Kraja AT,
Krajcoviechova A,
Kramer H,
Krämer BK,
Kronenberg F,
Kubo M,
Kühnel B,
Kuokkanen M,
Kuusisto J,
La Bianca M,
Laakso M,
Lange LA,
Langefeld CD,
Lee JJ,
Lehne B,
Lehtimäki T,
Lieb W,
Lim SC,
Lind L,
Lindgren CM,
Liu J,
Liu J,
Loeffler M,
Loos RJF,
Lucae S,
Lukas MA,
Lyytikäinen LP,
Mägi R,
Magnusson PKE,
Mahajan A,
Martin NG,
Martins J,
März W,
Mascalzoni D,
Matsuda K,
Meisinger C,
Meitinger T,
Melander O,
Metspalu A,
Mikaelsdottir EK,
Milaneschi Y,
Miliku K,
Mishra PP,
Mohlke KL,
Mononen N,
Montgomery GW,
Mook-Kanamori DO,
Mychaleckyj JC,
Nadkarni GN,
Nalls MA,
Nauck M,
Nikus K,
Ning B,
Nolte IM,
Noordam R,
O'Connell J,
O'Donoghue ML,
Olafsson I,
Oldehinkel AJ,
Orho-Melander M,
Ouwehand WH,
Padmanabhan S,
Palmer ND,
Palsson R,
Penninx BWJH,
Perls T,
Perola M,
Pirastu M,
Pirastu N,
Pistis G,
Podgornaia AI,
Polasek O,
Ponte B,
Porteous DJ,
Poulain T,
Pramstaller PP,
Preuss MH,
Prins BP,
Province MA,
Rabelink TJ,
Raffield LM,
Raitakari OT,
Reilly DF,
Rettig R,
Rheinberger M,
Rice KM,
Ridker PM,
Rivadeneira F,
Rizzi F,
Roberts DJ,
Robino A,
Rossing P,
Rudan I,
Rueedi R,
Ruggiero D,
Ryan KA,
Saba Y,
Sabanayagam C,
Salomaa V,
Salvi E,
Saum KU,
Schmidt H,
Schmidt R,
Schöttker B,
Schulz CA,
Schupf N,
Shaffer CM,
Shi Y,
Smith AV,
Smith BH,
Soranzo N,
Spracklen CN,
Strauch K,
Stringham HM,
Stumvoll M,
Svensson PO,
Szymczak S,
Tai ES,
Tajuddin SM,
Tan NYQ,
Taylor KD,
Teren A,
Tham YC,
Thiery J,
Thio CHL,
Thomsen H,
Thorleifsson G,
Toniolo D,
Tönjes A,
Tremblay J,
Tzoulaki I,
Uitterlinden AG,
Vaccargiu S,
van Dam RM,
van der Harst P,
van Duijn CM,
Velez Edward DR,
Verweij N,
Vogelezang S,
Völker U,
Vollenweider P,
Waeber G,
Waldenberger M,
Wallentin L,
Wang YX,
Wang C,
Waterworth DM,
Bin Wei W,
White H,
Whitfield JB,
Wild SH,
Wilson JF,
Wojczynski MK,
Wong C,
Wong TY,
Xu L,
Yang Q,
Yasuda M,
Yerges-Armstrong LM,
Zhang W,
Zonderman AB,
Rotter JI,
Bochud M,
Psaty BM,
Vitart V,
Wilson JG,
Dehghan A,
Parsa A,
Chasman DI,
Ho K,
Morris AP,
Devuyst O,
Akilesh S,
Pendergrass SA,
Sim X,
Böger CA,
Okada Y,
Edwards TL,
Snieder H,
Stefansson K,
Hung AM,
Heid IM,
Scholz M,
Teumer A,
Köttgen A,
Pattaro C
Nature genetics · 2019 · PMID 31152163
Questions about rs4441471
What is rs4441471?
rs4441471 is a single position in the genome, in or near the FAM49A gene. Published research associates it with estimated glomerular filtration rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4441471 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4441471 come from?
GWAS Catalog, Nature genetics 2019, PMID:31152163. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estimated glomerular filtration rate (rs4441471). MyGeneLog™. https://www.mygenelog.com/variants/rs4441471
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