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Who was studied 275,793 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.325 higher (95% confidence interval 0.22-0.43); p = 8 × 10−10.
Where it sits Chromosome 2, band 2q24.3 — between genes, 184.8 kb from PRPS1P1.
What each result means
A/ANo copy of the version the research linked to Systolic blood pressure (standard GWA). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Systolic blood pressure (standard GWA). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Systolic blood pressure (standard GWA). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature human behaviour · 2023 · PMID 37106081 · open access
Questions about rs4429489
What is rs4429489?
rs4429489 is a single position in the genome, in or near the near PRPS1P1 gene. Published research associates it with systolic blood pressure (standard gwa). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4429489 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs4429489 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4429489 come from?
GWAS Catalog, Nature human behaviour 2023, PMID:37106081. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6123Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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