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Thigh bone marrow fat fraction

FAM13A · rs4425336

Where this position leads

Condition: Osteoarthritis

rs4425336 Condition: Osteoarthritis Osteoarthritis Condition rs4425336 rs4425336 FAM13A

What the study found

Who was studied 37,589 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.05 higher (95% confidence interval 0.03-0.07); p = 1 × 10−8.

How common The A allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 4, band 4q22.1 — in an intron of FAM13A.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thigh bone marrow fat fraction compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thigh bone marrow fat fraction.
G/G Published research associates this genotype with typical/baseline likelihood of Thigh bone marrow fat fraction — no copies of the reported risk allele.
Source
MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites
Ahmed A, Cule M, Naz A, Thanaj M, Sorokin EP, Odoemelam CS, Whitcher B, Sattar N, Bell JD, Thomas EL, Yaghootkar H
Journal of obesity · 2025 · PMID 40922984 · open access

Questions about rs4425336

What is rs4425336?

rs4425336 is a single position in the genome, in or near the FAM13A gene. Published research associates it with thigh bone marrow fat fraction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4425336 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs4425336 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4425336 come from?

GWAS Catalog, Journal of obesity 2025, PMID:40922984. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Thigh bone marrow fat fraction (rs4425336). MyGeneLog™. https://www.mygenelog.com/variants/rs4425336

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