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Smoking behaviour (age at first cigarette)

MACROD2 · rs442467

Where this position leads

Condition: Smoking Behaviour and Nicotine Dependence

rs442467 Condition: Smoking Behaviour and Nicotine Dependence Smoking Behaviour and Nicotine Dependence Condition rs442467 rs442467 MACROD2

What the study found

Who was studied up to 146,117 European ancestry control.

The effect Each copy of the C allele shifted the measure 0.0279 higher (95% confidence interval 0.02-0.036); p = 7 × 10−11.

How common The C allele had a frequency of about 68% in the people studied.

Where it sits Chromosome 20, band 20p12.1 — in an intron of MACROD2.

What each result means

C/C Two copies of the version the research linked to Smoking behaviour (age at first cigarette). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Smoking behaviour (age at first cigarette). That is a smaller link than two copies.
T/T No copy of the version the research linked to Smoking behaviour (age at first cigarette). This is the starting point the study compared everyone against.
Source
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu M, Barnes DR, Bertelsen S, Chou YL
and 59 more — show all
Erzurumluoglu AM, Faul JD, Haessler J, Hammerschlag AR, Hsu C, Kapoor M, Lai D, Le N, de Leeuw CA, Loukola A, Mangino M, Melbourne CA, Pistis G, Qaiser B, Rohde R, Shao Y, Stringham H, Wetherill L, Zhao W, Agrawal A, Bierut L, Chen C, Eaton CB, Goate A, Haiman C, Heath A, Iacono WG, Martin NG, Polderman TJ, Reiner A, Rice J, Schlessinger D, Scholte HS, Smith JA, Tardif JC, Tindle HA, van der Leij AR, Boehnke M, Chang-Claude J, Cucca F, David SP, Foroud T, Howson JMM, Kardia SLR, Kooperberg C, Laakso M, Lettre G, Madden P, McGue M, North K, Posthuma D, Spector T, Stram D, Tobin MD, Weir DR, Kaprio J, Abecasis GR, Liu DJ, Vrieze S
CHD Exome+ Consortium · Consortium for Genetics of Smoking Behaviour
Biological psychiatry · 2019 · PMID 30679032

Questions about rs442467

What is rs442467?

rs442467 is a single position in the genome, in or near the MACROD2 gene. Published research associates it with smoking behaviour (age at first cigarette). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs442467 linked to?

On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.

Does having rs442467 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs442467 come from?

GWAS Catalog, Biological psychiatry 2019, PMID:30679032. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Smoking behaviour (age at first cigarette) (rs442467). MyGeneLog™. https://www.mygenelog.com/variants/rs442467

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