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Who was studied 252,438 European ancestry cases, 1,959,739 European ancestry controls, 9,826 East Asian ancestry cases, 140,446 East Asian ancestry controls, 754 South Asian ancestry cases, 52,054 South Asian ancestry controls, 9,485 African ancestry cases, 109,006 African ancestry controls, 3,447 Admixed American ancestry cases, 46,818 Admixed American ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0332 higher (95% confidence interval 0.024-0.042); p = 3 × 10−13.
How common The A allele had a frequency of about 19% in the people studied.
Where it sits Chromosome 7, band 7q11.23 — in an intron of DTX2P1-UPK3BP1-PMS2P11.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs4406337
What is rs4406337?
rs4406337 is a single position in the genome, in or near the DTX2P1-UPK3BP1-PMS2P11 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4406337 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs4406337 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4406337 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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