Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
Sensitive
Type 2 diabetes
IGF2BP2 · rs4402960
0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−23, with 8 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 6,377 European ancestry male cases, 5,794 European ancestry female cases, 22,243 European ancestry male controls, 34,619 European ancestry female controls; replicated in 12,938 European ancestry male cases, 8,553 European ancestry female cases, 904 Pakistani ancestry male cases, 274 Pakistani ancestry female cases, 30,273 European ancestry male controls, 25,374 European ancestry female controls, 2,088 Pakistani ancestry male controls, 384 Pakistani ancestry female controls.
The effect
Each copy of the T allele carried 1.13 times the odds of Type 2 diabetes (95% confidence interval 1.10-1.16); p = 2 × 10−23.
How common The T allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 3, band 3q27.2 — in an intron of IGF2BP2.
What ClinVar records
Classificationrisk factor for Diabetes mellitus type 2, susceptibility to; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2007-06-01.
ClinVar record 2435NM_006548.6(IGF2BP2):c.239+29254C>A
Change history
MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-11-01 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
How common each version is
GT
By ancestry gnomAD
East Asian
G 75.0% · T 25.0%
European (non-Finnish)
G 68.1% · T 31.9%
African / African American
G 47.9% · T 52.1%
South Asian
G 57.0% · T 43.0%
Admixed American (Latino)
G 71.0% · T 29.0%
Middle Eastern
G 70.4% · T 29.6%
Finnish
G 68.3% · T 31.7%
Ashkenazi Jewish
G 58.9% · T 41.1%
The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.
What each result means
G/GNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.
Nature genetics · 2012 · PMID 22885922 · open access
0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Type 2 diabetes (rs4402960). MyGeneLog™. https://www.mygenelog.com/variants/rs4402960