Standard

QT interval

near CALM2P1 · rs4399570

Where this position leads

Condition: QT Interval and Drug-Induced Long QT

What the study found

Who was studied 27,612 European ancestry women.

The effect Each copy of the G allele shifted the measure 0.048 higher (95% confidence interval 0.036-0.06); p = 2 × 10⁻¹⁴.

How common The G allele had a frequency of about 70% in the people studied.

Where it sits Chromosome 17, band 17q24.3 — between genes, 241.4 kb from CALM2P1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of QT interval — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with QT interval.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of QT interval compared to the general population.

Source

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders

van Duijvenboden S, Ramírez J, Young WJ, Orini M, Mifsud B, Tinker A, Lambiase PD, Munroe PB

Human molecular genetics · 2021 · PMID 34274964 · open access

Questions about rs4399570

What is rs4399570?

rs4399570 is a single position in the genome, in or near the near CALM2P1 gene. Published research associates it with qt interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4399570 linked to?

On MyGeneLog this position is linked to QT Interval and Drug-Induced Long QT. The research behind each link, and its sources, are set out on that condition page.

Does having rs4399570 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4399570 come from?

GWAS Catalog, Human molecular genetics 2021, PMID:34274964. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QT interval (rs4399570). MyGeneLog™. https://www.mygenelog.com/variants/rs4399570

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