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Who was studied 670,471 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.015 lower (95% confidence interval 0.01-0.02); p = 1 × 10−9.
How common The A allele had a frequency of about 16% in the people studied.
Where it sits Chromosome 14, band 14q24.3 — in an intron of TMEM63C.
What each result means
A/ATwo copies of the version the research linked to Self-reported math ability (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Self-reported math ability (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Self-reported math ability (MTAG). This is the starting point the study compared everyone against.
rs4396457 is a single position in the genome, in or near the TMEM63C gene. Published research associates it with self-reported math ability (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4396457 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs4396457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4396457 come from?
GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 301211922318Reads by AI crawlersClaude1ChatGPT2Google · Gemini1Perplexity1Meta AI9Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total30Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Self-reported math ability (MTAG) (rs4396457). MyGeneLog™. https://www.mygenelog.com/variants/rs4396457