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Who was studied at least 33,640 European ancestry cases, at least 43,456 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0641 higher (95% confidence interval 0.042-0.086); p = 2 × 10−8.
How common The A allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 12, band 12p11.22 — in an intron of TMTC1.
What each result means
A/ATwo copies of the version the research linked to Schizophrenia (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Schizophrenia (MTAG). That is a smaller link than two copies.
C/CNo copy of the version the research linked to Schizophrenia (MTAG). This is the starting point the study compared everyone against.
Translational psychiatry · 2021 · PMID 33479212 · open access
Questions about rs439639
What is rs439639?
rs439639 is a single position in the genome, in or near the TMTC1 gene. Published research associates it with schizophrenia (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs439639 linked to?
On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.
Does having rs439639 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs439639 come from?
GWAS Catalog, Translational psychiatry 2021, PMID:33479212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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