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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.00936 SD unit higher (95% confidence interval 0.0064-0.0123); p = 6 × 10−10.
How common The A allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 13, band 13q31.1 — between genes, 55.8 kb from LINC00377.
What each result means
A/ATwo copies of the version the research linked to Refractive error. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Refractive error. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Refractive error. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs4390475
What is rs4390475?
rs4390475 is a single position in the genome, in or near the near LINC00377 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4390475 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4390475 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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