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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 50,471 European ancestry cases, 969,623 European ancestry controls; replicated in 49,555 cases, 620,360 controls.
The effect
Each copy of the A allele carried 1.05 times the odds of Fracture of forearm (95% confidence interval 1.04-1.06); p = 1 × 10−19.
How common The A allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 7, band 7q21.3 — inside SEM1.
What each result means
A/ATwo copies of the version the research linked to Fracture of forearm. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Fracture of forearm. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Fracture of forearm. This is the starting point the study compared everyone against.
Nature genetics · 2023 · PMID 37919453 · open access
Questions about rs4389863
What is rs4389863?
rs4389863 is a single position in the genome, in or near the SEM1 gene. Published research associates it with fracture of forearm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4389863 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4389863 come from?
GWAS Catalog, Nature genetics 2023, PMID:37919453. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fracture of forearm (rs4389863). MyGeneLog™. https://www.mygenelog.com/variants/rs4389863