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Who was studied 983 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.11 higher; p = 5 × 10−14.
How common The T allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 19, band 19q13.32 — in a non-coding transcript of APOC1.
What each result means
C/CNo copy of the version the research linked to Cerebral amyloid deposition (PET imaging). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Cerebral amyloid deposition (PET imaging). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cerebral amyloid deposition (PET imaging). That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2021 · PMID 30361487 · open access
Questions about rs438811
What is rs438811?
rs438811 is a single position in the genome, in or near the APOE gene. Published research associates it with cerebral amyloid deposition (pet imaging). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs438811 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does rs438811 affect how medicines work?
APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs438811 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs438811 come from?
GWAS Catalog, Mol Psychiatry 2018, PMID:30361487. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 3632423220Reads by AI crawlersClaude0ChatGPT3Google · Gemini0Perplexity2Meta AI4Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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