Standard
Prostate-specific antigen levels
EHF · rs4378355
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Prostate-specific antigen levels compared to the general population.
C/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Prostate-specific antigen levels.
G/G
Published research associates this genotype with typical/baseline likelihood of Prostate-specific antigen levels — no copies of the reported risk allele.
Source
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
Hoffmann TJ,
Passarelli MN,
Graff RE,
Emami NC,
Sakoda LC,
Jorgenson E,
Habel LA,
Shan J,
Ranatunga DK,
Quesenberry CP,
Chao CR,
Ghai NR
and 17 more — show all
Aaronson D,
Presti J,
Nordström T,
Wang Z,
Berndt SI,
Chanock SJ,
Mosley JD,
Klein RJ,
Middha M,
Lilja H,
Melander O,
Kvale MN,
Kwok PY,
Schaefer C,
Risch N,
Van Den Eeden SK,
Witte JS
Nature communications · 2017 · PMID 28139693 · open access
Questions about rs4378355
What is rs4378355?
rs4378355 is a single position in the genome, in or near the EHF gene. Published research associates it with prostate-specific antigen levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4378355 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4378355 come from?
GWAS Catalog, Nat Commun 2017, PMID:28139693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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