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Who was studied 228,926 European ancestry cases, 1,611,415 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0307 higher (95% confidence interval 0.023-0.038); p = 1 × 10−15.
How common The T allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 3, band 3q24 — in an intron of HLTF-AS1.
What each result means
C/CNo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40645996 · open access
Questions about rs4377452
What is rs4377452?
rs4377452 is a single position in the genome, in or near the HLTF-AS1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4377452 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs4377452 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4377452 come from?
GWAS Catalog, Nature communications 2025, PMID:40645996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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