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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 19,493 European ancestry individuals with low FEV1 measurements, 9,808 European ancestry individuals with high FEV1 measurements.
The effect
Each copy of the C allele shifted the measure 0.143 lower (95% confidence interval 0.1-0.18); p = 5 × 10−13.
Where it sits Chromosome 10, band 10p13 — in an intron of CDC123.
What each result means
C/CTwo copies of the version the research linked to Lung function (low FEV1 vs high FEV1). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Lung function (low FEV1 vs high FEV1). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Lung function (low FEV1 vs high FEV1). This is the starting point the study compared everyone against.
The Lancet. Respiratory medicine · 2015 · PMID 26423011 · open access
Questions about rs4372354
What is rs4372354?
rs4372354 is a single position in the genome, in or near the CDC123 gene. Published research associates it with lung function (low fev1 vs high fev1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4372354 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4372354 come from?
GWAS Catalog, The Lancet. Respiratory medicine 2015, PMID:26423011. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung function (low FEV1 vs high FEV1) (rs4372354). MyGeneLog™. https://www.mygenelog.com/variants/rs4372354