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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 96,385 European ancestry individuals (MTAG effective sample size boosted by aortic valve function and stenosis samples).
The effect
Each copy of the A allele shifted the measure 0.0367 lower (95% confidence interval 0.027-0.047); p = 2 × 10−12.
How common The A allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 4, band 4q12 — in an intron of PDGFRA.
What each result means
A/ATwo copies of the version the research linked to Aortic valve peak velocity (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Aortic valve peak velocity (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Aortic valve peak velocity (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs4368668
What is rs4368668?
rs4368668 is a single position in the genome, in or near the PDGFRA gene. Published research associates it with aortic valve peak velocity (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4368668 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4368668 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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