0 121227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,711 African American or Afro-Caribbean cases, 119,220 African American or Afro-Caribbean controls, 1,845 Hispanic or Latin American cases, 57,348 Hispanic or Latin American controls, 245 East Asian ancestry cases, 6,518 East Asian ancestry controls, 16,283 European ancestry cases, 428,468 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0784 lower (95% confidence interval 0.058-0.099); p = 1 × 10−11.
How common The A allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 16, band 16p11.2 — in an intron of SETD1A.
What each result means
A/ATwo copies of the version the research linked to Psoriasis (PheCode 696.4). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Psoriasis (PheCode 696.4). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriasis (PheCode 696.4). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs4346218
What is rs4346218?
rs4346218 is a single position in the genome, in or near the SETD1A gene. Published research associates it with psoriasis (phecode 696.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4346218 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4346218 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4346218 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 121227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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