0 17121112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others12Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,809 East Asian ancestry cases, 172,656 East Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.486 higher (95% confidence interval 0.43-0.54); p = 2 × 10−67.
How common The T allele had a frequency of about 47% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DPA1.
What each result means
C/CNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4345439 is a single position in the genome, in or near the HLA-DPA1 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4345439 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs4345439 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4345439 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 17121112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others12Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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