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Who was studied 3,620 European ancestry individuals; replicated in 1,290 European ancestry individuals.
The effect
Each copy of the C allele carried 1.45 times the odds of Thyroid volume (95% confidence interval 1.32-1.59); p = 3 × 10−13.
How common The C allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 15, band 15q21.2 — in an intron of FGF7.
What each result means
C/CTwo copies of the version the research linked to Thyroid volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Thyroid volume. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Thyroid volume. This is the starting point the study compared everyone against.
American journal of human genetics · 2011 · PMID 21565293
Questions about rs4338740
What is rs4338740?
rs4338740 is a single position in the genome, in or near the C15orf33 gene. Published research associates it with thyroid volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4338740 linked to?
On MyGeneLog this position is linked to Thyroid Volume. The research behind each link, and its sources, are set out on that condition page.
Does having rs4338740 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4338740 come from?
GWAS Catalog, Am J Hum Genet 2011, PMID:21565293. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 324211722319Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others9Total32Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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