Standard

Spherical equivalent

RBFOX1 · rs4332760

Where this position leads

Condition: Myopia

rs4332760 Condition: Myopia Myopia Condition rs4332760 rs4332760 RBFOX1

What the study found

Who was studied 41,073 European ancestry individuals, 2,610 Erasmus Rucphen (founder/genetic isolate) individuals, 509 Talana (founder/genetic isolate) individuals, 15,044 East Asian ancestry individuals, 2,275 Malay ancestry individuals, 2,110 Indian ancestry individuals, 2,506 Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0912 higher (95% confidence interval 0.061-0.121); p = 3 × 10−9.

How common The C allele had a frequency of about 62% in the people studied.

Where it sits Chromosome 16, band 16p13.3 — in an intron of RBFOX1.

What each result means

C/C Two copies of the version the research linked to Spherical equivalent. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Spherical equivalent. That is a smaller link than two copies.
G/G No copy of the version the research linked to Spherical equivalent. This is the starting point the study compared everyone against.
Source

Questions about rs4332760

What is rs4332760?

rs4332760 is a single position in the genome, in or near the RBFOX1 gene. Published research associates it with spherical equivalent. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4332760 linked to?

On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.

Does having rs4332760 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4332760 come from?

GWAS Catalog, Nat Genet 2018, PMID:29808027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Spherical equivalent (rs4332760). MyGeneLog™. https://www.mygenelog.com/variants/rs4332760

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