0 6213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 449,734 European ancestry individuals, 69,501 European ancestry ER+ breast cancer cases, 105,974 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−16.
Where it sits Chromosome 8, band 8q21.13 — between genes, 135.9 kb from HNF4G.
What each result means
C/CNo copy of the version the research linked to Chronotype and ER+ breast cancer. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Chronotype and ER+ breast cancer. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Chronotype and ER+ breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4321976 is a single position in the genome, in or near the near HNF4G gene. Published research associates it with chronotype and er+ breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4321976 linked to?
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs4321976 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4321976 come from?
GWAS Catalog, Journal of sleep research 2024, PMID:37380357. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6213Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Chronotype and ER+ breast cancer (rs4321976). MyGeneLog™. https://www.mygenelog.com/variants/rs4321976