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Glycated hemoglobin levels

ANK1 · rs4317621

What the study found

Who was studied 146,806 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0035 higher; p = 8 × 10−9.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 8, band 8p11.21 — in an intron of ANK1.

What each result means

A/A Two copies of the version the research linked to Glycated hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Glycated hemoglobin levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Glycated hemoglobin levels. This is the starting point the study compared everyone against.
Source

Questions about rs4317621

What is rs4317621?

rs4317621 is a single position in the genome, in or near the ANK1 gene. Published research associates it with glycated hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4317621 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4317621 come from?

GWAS Catalog, Nature genetics 2021, PMID:34059833. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Glycated hemoglobin levels (rs4317621). MyGeneLog™. https://www.mygenelog.com/variants/rs4317621

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